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For example, SP and CGRP promote mast cell degranulation, while quercetin significantly inhibits the production of the neuropeptides SP, CGRP, and NGF in TDI-mediated allergic reactions, thereby reducing allergic symptoms ( 5 Discussion 5.1 Advantages of natural products Nasal administration, being non-invasive and convenient, can circumvent first-pass metabolism, enable rapid absorption, and bypass the BBB, thus dramatically improving drug bioavailability and efficacy

Baker J, Liu JP, Robertson EJ, Efstratiadis A

Randomized placebo-controlled clinical trial of lorcaserin for weight loss in type 2 diabetes mellitus: The BLOOM-DM Study